Docker push to Nexus fails


I’m experiencing weird behavior when pushing a docker image to Nexus. Sometimes it works, sometimes it fails (with the same code).
When it fails, I get following error in the Nexus log:

An exception occurred determining the content type of asset v2/-/blobs/sha256:b28fee045e5167e7325b62ac7082d69622ee98e189738993f4dec0eaa1fb9b58 in repository docker-release
Error: PUT /v2/…: 400 - Invalid docker content v2/-/blobs/sha256:b28fee045e5167e7325b62ac7082d69622ee98e189738993f4dec0eaa1fb9b58

Nexus is running on a single server instance.
Anybody who also experienced this kind of behaviour?