Nexus proxy with two network interface

Hi Team,
we have nexus repository VM with two network interface.
1st network interface is: for internet access .
2nd network interface is for connectivity with VMs which are using the nexus.
fqdn and IP of

docker repository is working fine. We able to pull the docker images
When we try to use docker proxy , it is not working.
Quick question:
For nexus proxy the two network interface is OK or should we proceed with single network interface?